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硕士导师简介—杨细飞
2017-10-12 10:28  

姓名:杨细飞        E-mail:xifeiyang@gmail.com

所在单位:深圳市疾病预防控制中心/深圳市预防医学研究所,广东省医学重点实验室

职称:研究员、教授

职务:毒理研究所副所长

基本情况

杨细飞,男,39岁(1978年6月出生),博士(MD, PhD),研究员,教授、美国哈佛大学博士后,博士研究生导师,广东省杰出医学人才、深圳市高层次人才、深圳市海外高层次“孔雀计划”人才。中国毒理学会理事(候任),中国毒理学会神经毒理专业委员会委员。研究方向为脑衰老及神经退行性疾病的风险因素、分子标志物及防治。主持国家自然科学基金、广东省自然科学基金、广东省科技计划项目等12项 ;获2016年中国毒理学会全国优秀青年科技奖、广东省科学技术奖二等奖、中华医学奖三等奖、深圳市自然科学奖一等奖及深圳市科技进步奖二等奖各1项;共发表SCI论文70余篇,其中以第一作者或通讯作者在Part Fibre ToxicolMol NeurobiolArch ToxicolToxicol SciJ Neurochem等SCI杂志上发表论文40余篇;申请及授权国家发明专利5项;国际及全国性学术会议受邀报告8次;编写专著3部(编委,国内专著2部、外文专著1部);指导硕士、博士及博士后20名;SCI期刊Front Neurosci杂志编委。

代表性论文(#共同第一组作者,*通讯作者)

1. XianfengHuang#, Jing Wang#, Xiao Chen#, Pan Liu,Shujing Wang1, Fangchen Song, ZaijunZhang, Feiqi Zhu, Xinfeng Huang, Jianjun Liu, Guoqiang Song,Peter S. SpencerandXifei Yang*(通讯作者).ThePrenylflavonoidXanthohumolTargets Multiple Molecular Pathways to Reduce Alzheimer-like Changes in the Neuro2a/APPsweCell Model of AD.Fronters in Pharmacology. In press, 2018.

2. Dian Wanga,1, Haitao Yua,1, Benhong Xub, Hua Xua,*, Zaijun Zhangc, Xiaohu Renb, Jianhui Yuanb, Jianjun Liub, Yi Guod,Peter S. SpencereandXifei Yang*(通讯作者).TRPC1 Depletion Causes Striatal Neuronal Cell Apoptosis and Proteomic Alterations in Mice.Frontiers in Aging Neuroscience. 2018,In press.

3. Haitao Yu, Xuemei Lin, Dian Wang, Zaijun Zhang, Yi Guo, Xiaohu Ren, Benhong Xu, Jianhui Yuan, Jianjun Liu,Peter S. Spencer, Jianzhi Wang andXifei Yang*(通讯作者). Mitochondrial Molecular Abnormalities Revealed by Proteomic Analysis of Hippocampal Organelles of Mice Triple Transgenic for Alzheimer Disease.Frontiers in Molecular Neuroscience.In press 2018.

4. Yu H#, Wang D#, Zou L, Zhang Z, Xu H*, Zhu F, Ren X, Xu B, Yuan J, Liu J, Spencer PS, Yang X*(通讯作者). Proteomic alterations of brain subcellular organelles caused by low-dose copper exposure: implication for Alzheimer's disease.Arch Toxicol. 2018 Jan 30. doi: 10.1007/s00204-018-2163-6. [Epub ahead of print].[PMID:29383422]

5. Nie L, Xia J, Li H, Zhang Z, Yang Y, Huang X, He Z, Liu J,Yang X*(通讯作者). Ginsenoside Rg1 Ameliorates Behavioral Abnormalities and Modulates the Hippocampal Proteomic Change in Triple Transgenic Mice of Alzheimer's Disease.Oxid Med Cell Longev. 2017; 2017:6473506. doi: 10.1155/2017/6473506. Epub 2017 Oct 24. [PMID: 29204248]

6. Nie L, Wei G, Peng S*, Qu Z, Yang Y, Yang Q, Huang X, Liu J, Zhuang Z,Yang X*(通讯作者). Melatonin ameliorates anxiety and depression-like behaviors and modulates proteomic changes in triple transgenic mice of Alzheimer's disease.Biofactors.2017; 43(4):593-611. [PMID: 28608594]

7. Ying M, Sui X, Zhang Y, Sun Q, Qu Z, Luo X, Chang RC, Ni J, Liu J,Yang X*(通讯作者). Identification of novel key molecules involved in spatial memory impairment in triple transgenic mice of Alzheimer's disease.Mol Neurobiol. 2017; 54(5):3843-3858.[PMID: 27335030]

8. Lin X, Wei G, Huang Z, Qu Z, Huang X, Xu H*, Liu J, Zhuang Z, Yang X*(通讯作者).Mitochondrial Proteomic Alterations Caused by Long-term Low-dose Copper Exposure in Mouse Cortex.Toxicol Lett. 2016; 263:16-25.[PMID: 27769873]

9. He K#, Qi F#, Guo C, Zhan S, Xu H*, Liu J, Yang X*(通讯作者).Movement deficits and neuronal loss in basal ganglia in TRPC1 deficient mice.Oncotarget. .2016;7(43):69337-69346.[PMID: 27738307]

10. Xing R, Zhang Y, Xu H*, Luo X, Chang RC, Liu J, Yang X* (通讯作者). Spatial memory impairment by TRPC1 depletion is ameliorated by environmental enrichment.Oncotarget. 2016; 7(19):27855-27873. [PMID: 27034165]

11. Yang X*(通讯作者), Zhang Y, Xu H, Luo X, Yu J, Liu J, Chang RC. Neuroprotection of Coenzyme Q10 in Neurodegenerative Diseases.Curr Top Med Chem. 2016; 16(8):858-866.[PMID: 26311425]

12. Zhang Y, Xing R, Luo X, Xu H, Chang RC, Zou L, Liu J,Yang X*(通讯作者).Anxiety-like Behavior and Dys-regulation of miR-34a in Triple Transgenic Mice of Alzheimer’s Disease.Eur Rev Med Pharmacol Sci.2016; 20: 2853-2862.[PMID: 27424985]

13. Ma Q, Ying M, Sui X, Huang H, Yang L, Huang X, Zhuang Z, Liu J,Yang X* (通讯作者).Chronic copper exposure causes spatial memory impairment, selective loss of hippocampal synaptic proteins, and activation of PKR/eIF2α pathway in mice.J Alzheimers Dis. 2015; 43(4): 1413-1427.[PMID: 25159668]

14. Yu J, Luo X, Xu H*, Ma Q, Yuan J, Li X, Chang RC, Qu Z, Huang X, Zhuang Z, Liu J,Yang X*(通讯作者).Identification of the key molecules involved in chronic copper exposure-aggravated memory impairment in transgenic mice of Alzheimer's disease using proteomic analysis.J Alzheimers Dis.2015; 44(2):455-469. [PMID: 25352456]

15. Wu Y, Luo X, Liu X, Liu D, Wang X, Guo Z, Zhu L, Tian Q, Yang X*(通讯作者), Wang JZ*.Intraperitoneal Administration of a Novel TAT-BDNF Peptide Ameliorates Cognitive Impairments via Modulating Multiple Pathways in Two Alzheimer's Rodent Models.Sci Rep. 2015; 5:15032. [PMID: 26463268]

16. Sui X, Ren X, Huang P, Li S, Ma Q, Ying M, Ni J, Liu J*,Yang X*(通讯作者).Proteomic analysis of serum proteins in triple transgenic Alzheimer's disease mice: implications for identifying biomarkers for use to screen potential candidate therapeutic drugs for early Alzheimer's disease.J Alzheimers Dis.2014; 40(3):575-586.[PMID: 24496070]

17. Sui X, Liu J,Yang X*(通讯作者).Cerebrospinalfluidbiomarkers of Alzheimer’sdisease.Neurosci Bull. 2014; 30(2): 233-242.[PMID: 24733653]

18. Luo Y, Liu X, Zheng Q, Wan X, Ouyang S, Yin Y, Sui X, Liu J,Yang X*(通讯作者).Hydrogen sulfide prevents hypoxia-induced apoptosis via inhibition of an H(2)O(2)-activated calcium signaling pathway in mouse hippocampal neurons.Biochem Biophys Res Commun. 2012;425(2):473-477. [PMID: 22846576]

19. Yang X, He C, Li J, Chen H,Ma Q, Sui X, Tian S,Ying M, Zhang Q,Luo Y, Zhuang Z, Liu J*. Uptake of silica nanoparticles: neurotoxicity and Alzheimer-like pathology in human SK-N-SH and mouse neuro2a neuroblastoma cells.Toxicol Lett. 2014; 229(1):240-249.[PMID: 24831964]

20. Zhang C*, #,Yang X#, Li L, Sui X, Tian Q, Wei W, Wang J, Liu G*. Hypoxia induced tau phosphorylation and memory deficit in rats.Neurodegener Dis.2014; 14(3):107-116. [PMID: 24993525]

21. Yang X, Shen Z, Zhang B, Yang J, Hong WX, Zhuang Z, Liu J*. Silica nanoparticles capture atmospheric lead: Implications in the treatment of environmental heavy metal pollution.Chemosphere. 2013; 90(2):653-656. [PMID: 23084516]

22. Yang XF, Yang Y, Fu ZQ, Li Y, Feng J, Luo JZ, Zhang QY, Wang Q and Tian Q*. Melatonin ameliorates Alzheimer-like pathological changes and spatial memory retention impairment induced by calyculin A.J Psychopharmacol.2011; 25(8):1118-25. [PMID: 20542922]

23. Yang X, Liu J*, He H, Zhou L, Gong C, Wang X, Yang L, Yuan J, Huang H, He L, Zhang B, Zhuang Z. SiO2nanoparticles induce cytotoxicity and protein expression alteration in HaCaT cells.Part Fibre Toxicol. 2010 19; 7(1):1. [PMID: 20180970]

24. Yang X, Yang Y, Li G*, Wang J, Yang ES.Coenzyme Q10 attenuates beta-amyloid pathology in the aged transgenic mice with Alzheimer presenilin 1 mutation.J Mol Neurosci.2008; 34(2):165-171. [PMID: 18181031]

25. Yang Y#,Yang XF#, Wang YP, Tian Q, Wang XC, Li HL, Wang Q and Wang JZ*. Inhibition of protein phosphatases induces transport deficits and axonopathy.J Neuochem.2007; 102(3): 878-886.[PMID: 17472709]

26. Zhang G, Zhang T, Wu L, Zhou X, Gu J, Li C, Liu W, Long C, Yang X, Shan L, Xu L, Wang Y, Sun Y, Zhang Z. Neuroprotective Effect and Mechanism of Action of Tetramethylpyrazine Nitrone for Ischemic Stroke Therapy.Neuromolecular Med. 2018 Mar; 20(1):97-111. [PMID: 29411248]

27. Guo CN, Yang WJ, Zhan SQ,Yang XF, Chen MC, Fuller PM, Lu J. Targeted disruption of supraspinal motor circuitry reveals a distributed network underlying Restless Legs Syndrome (RLS)-like movements in the rat.Sci Rep. 2017 Aug 29; 7(1):9905. [PMID: 28852150]

28. Zhang G, Zhang T, Li N, Wu L, Gu J, Li C, Zhao C, Liu W, Shan L, Yu P,Yang X, Tang Y, Yang GY, Wang Y, Sun Y, Zhang Z. Tetramethylpyrazine nitrone activates AKT/CREB through increasing BDNF expression to promote post-ischemic neuroregeneration and recovery of neurological functions in rats.Br J Pharmacol. 2017 Nov 21. doi: 10.1111/bph.14102. [Epub ahead of print] [PMID: 29161771]

29. Guo B, Hu S, Zheng C, Wang H, Luo F, Li H, Cui W,Yang X, Cui G, Mak S, Choi TC, Ma ED, Wang Y, Lee SMY, Zhang Z, Han Y. Substantial protection against MPTP-associated Parkinson's neurotoxicity in vitro and in vivo by anti-cancer agent SU4312 via activation of MEF2D and inhibition of MAO-B.Neuropharmacology. 2017; 126:12-24. [PMID: 28807675]

30. Du LL, Wang L,Yang XF, Wang P, Li XH, Chai DM, Liu BJ, Cao Y, Xu WQ, Liu R, Tian Q, Wang JZ, Zhou XW. Transient Receptor Potential-canonical 1 is Essential for Environmental Enrichment-Induced Cognitive Enhancement and Neurogenesis.Mol Neurobiol. 2017; 54(3):1992-2002. [PMID: 26910815]

31. Li N, Hu P, Xu T, Chen H, Chen X, Hu J,Yang X, Shi L, Luo JH, Xu J.iTRAQ-based proteomic analysis of APPSw,Ind mice provides insights into the early changes in Alzheimer's disease.Curr Alzheimer Res. 2017; 14(10):1109-1122. [PMID: 28730955]

32. Guo CN, Machado NL, Zhan SQ,Yang XF, Yang WJ, Lu J.Identification of Cholinergic Pallidocortical Neurons.CNS Neurosci Ther. 2016; 22(10):863-865. [PMID: 27577268]

33. Chu TT, Gao N, Li QQ, Chen PG,Yang XF, Chen YX, Zhao YF, Li YM.Specific Knockdown of Endogenous Tau Protein by Peptide-Directed Ubiquitin-Proteasome Degradation.Cell Chem Biol. 2016; 23(4):453-61. [PMID: 27105281]

34. Ho WL, Leung Y, Cheng SS, Lok CK, Ho YS, Baum L,Yang X, Chiu K, Chang RC. Investigating degeneration of the retina in young and aged tau P301L mice.Life Sci.2015; 124:16-23. [PMID: 25592136]

35. Ho YS,Yang X, Yeung SC, Chiu K, Lau CF, Tsang AW, Mak JC, Chang RC*.Cigarette smoking accelerated brain aging and induced pre-Alzheimer-like neuropathology in rats.PLoS One. 2012; 7(5):e36752. [PMID: 22606286]

36. Ho YS,Yang X, Lau JC, Hung CH, Wuwongse S, Zhang Q, Wang J, Baum L, So KF, Chang RC*.Endoplasmic reticulum stress induces tau pathology and forms a vicious cycle: implication in Alzheimer's disease pathogenesis.J Alzheimers Dis.2012; 28(4):839-854. [PMID: 22101233]

37. Ho YS,Yang X, Yeung SC, Chiu K, Lau CF, Tsang AW, Mak JC, Chang RC*.Cigarette smoking accelerated brain aging and induced pre-Alzheimer-like neuropathology in rats.PLoS One. 2012; 7(5):e36752. [PMID: 22606286]

38. Ho YS, Yu MS,Yang XF, So KF, Yuen WH, Chang RC*. Neuroprotective effects of polysaccharides from wolfberry, the fruits of Lycium barbarum, against homocysteine-induced toxicity in rat cortical neurons.J Alzheimers Dis. 2010; 19(3):813-827. [PMID: 20157238]

承担的课题

1. 国家自然科学基金中美合作与国际交流项目、20187/01.8-10、直接经费8.52万元、主持。

2. 国家自然科学基金面上项目、81673134、Tubby调控miR-195介导低剂量慢性铜暴露致Alzheimer病神经退化的机制研究、2017/01-2020/12、72.0万元、在研、主持。

3. 国家自然科学基金青年项目、81102154、PKR激活在铜致空间记忆损伤中的作用及机制研究、2012/01-2014/12、21.0万元、已结题、主持。

4. 广东省自然科学基金/自由申请项目、2014A030313715、MicroRNA-34a调控早期阿尔茨海默病神经精神障碍的表观遗传学机制研究、10.0万元、2015/01-2017/12、在研、主持。

5. 广东省科技计划项目/(技术开发及产业化类别)公益研究与能力建设、项目编号、通过“组学”技术高通量筛选脑梗塞并发抑郁症的(联合)生物标志物研究、2015/01/01-2017/12/31、在研、主持。

6. 广东省医学科研基金项目、A2013598、PKR激活在Alzheimer病tau病理发展中的作用及机制研究、2013/09-2015/09、1.0万元、在研、主持。

7. 广东省医学科研基金资助项目、B2012322、辅酶Q10对阿尔茨海默病tau病理损伤的保护作用研究、2012/09-2014/09,已结题,主持。

8. 2016年深圳市基础研究项目/自由探索项目、JCYJ20160428143433768、基于外周血淋巴细胞蛋白质组学的早期AD分子标志物的筛选与鉴定、2016/07-2019/08、15万元、主持人。

9. 深圳市知识创新计划-基础研究项目重点项目、JCYJ20130329103949650、抑制海马microRNA-34a改善Alzheimer病早期焦虑障碍的机制研究、2013/07-2015/07、30.0万元、已结题、主持。

10. 深圳市科学研究计划(医疗卫生类)、201202086、PKR激活促进Alzheimer病β-淀粉样蛋白过量生成的机制研究、2012/07-2014/07、1.0万元、已结题、主持。

11. 德国和香港联合资助的国际合作项目(Germany/Hong Kong Joint Research Scheme)、G_HK023/06、“The Effect of Imbalance of Kinases and Protein Phosphatases on Deposit of β-amyloid and Tau Pathology in Double Transgenic APP/PS1 Mice”、2006/06-2008/06、8.0万元(港币)、已结题、课题第二完成人。

12. 国家自然科学基金面上项目、81773395、三氯生暴露通过miR-17家族介导线粒体自噬和凋亡致雄性生殖细胞损伤的机制研究、2018/01-2021/12、直接经费60万元、在研、参与。

13. 国家自然科学基金资助项目、30960110、钙敏感受体在缺氧诱导的Aβ过量生成中的作用及其分子机制、2010/01-2012/12、24.0万元、已结题、课题第二完成人。

14. 国家自然科学基金资助项目,30500271、细胞内磷酸化tau蛋白降解途径的研究、2006/01-2008/12、21.0万元、已结题、课题主要完成人。

15. 国家自然科学基金资助项目、30400171、APP及其代谢片段对tau磷酸化和运输的影响、2005/01-2007/12、20.0万元、已结题、课题主要完成人。

16. 广东省自然科学基金/重点项目、S2012020010903、三氯乙烯致肝细胞毒性中SET相关的表观遗传调控机制研究、2013/01-2015/12、30.0万元、在研、课题第二负责人。

17. 江西省自然科学基金面上项目、20142BAB205030、硫化氢对缺血缺氧诱导β-淀粉样蛋白代谢的影响及机制、2014/07-2016/06、5.0万元、在研、课题第二负责人。18. 江西省自然科学基金面上项目、20132BAB205020、硫化氢对内质网应激诱导tau蛋白过度磷酸化的影响及机制、2013/01-2014/12、2.0万元、已结题、课题第二负责人。

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